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Malaria remains one of the most important diseases in the world, being lethal to 610 thousand individuals annually. The widespread resistance of P. falciparum to antimalarials emphasizes the urgent need for new therapies, as treatment remains the primary strategy to control the disease. Although combinations of synthet…

Introduction: The primary malignant bone tumors of the lower extremities are rare tumor entities occurring mostly amongst adolescent and young adult age groups. In a metastasis free situation with adequate therapy, the overall survival rate can reach up to 90%. Since the end of the 20th century limb salvage has become …

Background: EBV Nuclear Antigen 1 (EBNA1) is a multifunctional protein of 641 amino acids. In host cells it is essential for the maintenance, replication and transcription of the EBV genome in expressed in both latent and lytic modes of infection. Objetive this study aimed to characterize the EBNA1 gene in cases of Inf…

Bruxism is characterized by teeth grinding, divided into sleep bruxism and daytime bruxism, it can be classified into primary and secondary. The main causative factors are poor sleep quality, stress, anxiety, alcohol consumption and smoking. The objective of this study was to investigate, through a literature review, t…

This paper presents a one-month lead-time predictive model of atmospheric drought developed at the Scientific Research Hydrometeorological Institute. The model is based on a dynamic-stochastic approach to constructing a regression predictive equation. From the set of existing methods for constructing regression equatio…

Background: Naringin, a natural flavonoid prevalent in citrus fruits, is known for its antioxidant, anti-inflammatory, and antitumor properties. Recent studies suggest its potential influence on bone metabolism, proposing it as an anti-osteoporotic agent. However, specific mechanisms of action remain unclear.Objective:…

Environmental contaminants are considered a significant food safety risk. The rising population increased food production and industrialization have accentuated the importance of addressing food contamination. The primary causes of these contaminants in food include agricultural practices, industrial activities, waste …

Introduction: Postural Orthostatic Tachycardia Syndrome (POTS) belongs to a group of orthostatic intolerance syndromes. It is defined by the increase in heart rate ≥30 bpm or heart rate higher than 120/min during first 10 minutes after standing, without significant decrease in blood pressure. It is a rare disease, ty…

Hematopoietic Stem Cell Transplantation (HSCT) is a curative treatment for certain blood disorders, but can lead to complications such as Autoimmune Cytopenia (AIC), particularly Autoimmune Hemolytic Anemia (AIHA). AIHA after HSCT often involves donor-derived antibodies attacking donor red blood cells, but this case re…

In the healthy gut mucosa, epithelial cells lining the lumen experience low oxygen levels, typically less than 2%, referred to as physiological hypoxia or physioxia. This gradient is maintained by the diffusion of oxygen from blood vessels along the crypt-villus axis, creating varying degrees of hypoxia within the muco…

Background: Breastfeeding is the recommended feeding method for infants due to its ease, health benefits, and cost-effectiveness. However, there is limited understanding of Exclusive Breastfeeding (EBF) in pastoral communities, such as the Sawena district in Ethiopia.Objective: To assess the prevalence and factors asso…

Purpose: Patients with Multiple Myeloma (MM) who relapse after exposure to lenalidomide in the context of their first line therapeutic strategy are becoming a growing and clinically relevant population. We performed a systematic review of available clinical trials evaluating the efficacy, in terms of Progression-Free …

Patients in the Neonatal Intensive Care Unit (NICU) have high mortality and morbidity rates due to their low birth weight or being preterm. Due to their vulnerability, neonates require close monitoring so that timely treatment can be performed. However, current, state-of-the-art technologies for continuous vital sign m…