The objectives of this study is to summarize and analyze the clinical and pathological data of patients with feeding jejunostomy, evaluate its clinical application value and risk, and study the optimal selection of enteral nutrients. The clinical data of 238 patients who underwent feeding jejunostomy in Beijing Shijitan Hospital, Capital Medical University, from September 1, 2017 to July 31, 2021 were retrospectively studied. The serious complications and treatment of patients were summarized and analyzed. Serious complications included anastomotic fistula, postoperative bleeding, and so on. Complications related to jejunal feeding stoma included: tube folded, intestinal stenosis at the stoma, and others. The symptoms of some enteral nutrition patients with abdominal pain, abdominal distension and diarrhea were improved by changing the type of enteral nutrients and increasing dietary fiber. Feeding jejunostomy can effectively solve the enteral nutrition problems of upper gastrointestinal anastomotic leakage, perforation, obstruction and functional eating disorder, can also be used as a separate means of enhance enteral nutrition support, but also can cause severe complications, and even death. Compliance with surgical indications is as important as mastery of surgical technical details. Reasonable use of enteral nutrients can achieve better nutritional support effect.