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Cutaneous Melanoma (CM), with its profound heterogeneity and capacity for therapy resistance, represents a persistent challenge in oncology. This review charts the evolution of management strategies from a refined understanding of molecular pathogenesis towards the advent of highly selective therapeutic modalities. Whi…

Botanical innovations hold unprecedented potential to address pressing global challenges in human health and environmental sustainability. However, a significant disconnect persists between scientific advancement and public understanding, often termed 'plant awareness disparity,' limiting the societal impact of these i…

One solution to eliminate toxins is to trap them in polymer nanoparticles. Alpha clostridial toxins typically form pores in the cell membrane, allowing them to enter cells and exert their destructive and deadly effects. However, using red blood cells whose membranes are coated with clostridial nanoparticles and toxins …

Background: Goldbach’s strong conjecture states that every even integer E ? 4 can be written as the sum of two primes. This work presents the “Goldbach Circle” as a unified geometric–analytic model designed to predict where symmetric prime pairs typically occur around the midpoint E/2.Methods: A smooth prime-density pr…

Intelligence quotient IQ is a number claiming to measure the intelligence of a human been. This number is established based on psychometric testing. In use in the English-speaking world, there is a variety of individually administered IQ tests, having different degree of difficulty. In this paper, we propose a computat…

Khao Sok National Park is a protected area in Surat Thani Province, southern Thailand, in the western part of Surat Thani City. It consisted of the lowlands of the lower Phuket Mountain range, of the Indo-Malayan Mountain formations. Mountains are made of limestone and mostly covered with dense, moist tropical forest s…

Significance: Suicide is now the second leading cause of death among adolescents, with nearly 90% of youth suicidal behaviors attributable to adverse childhood experiences. Yet current trauma treatments fail 30-50% of patients, with dropout rates reaching 26-40%. This review addresses a critical gap by quantifying trea…

Background: Focal Segmental Glomerulosclerosis (FSGS), a major cause of end-stage renal disease, is characterized by podocyte loss via apoptosis and cytoskeletal disruption. Although dysregulation of the Hippo-YAP pathway is implicated in podocyte injury, upstream regulators of this pathway in FSGS pathogenesis remain …

After decades of empirical research, I found myself writing fewer data-driven papers and more reflective notes and autoethnographic vignettes. This shift is not a retreat from science but an extension of it. The act of reflection allows scientists to make sense of their professional lives, intellectual commitments, and…

Kikuchi-Fujimoto Disease is a rare, benign, self-limiting cause of lymphadenopathy, typically characterized by fever and tender cervical lymph nodes, affecting mostly young women. Clinicians should consider Kikuchi disease in the differential diagnosis of causes of lymphadenopathy to avoid misdiagnosis as lymphoma, sys…

Guest satisfaction is often linked to cleanliness in the hospitality industry, however, the complexity of microbial communities colonizing built environments is neglected. Recent breakthroughs in biomedical research as well as environmental science have established that the hotel microbiome--the bacteria, fungi, and …

Tick-borne zoonotic diseases baffle clinicians and traumatize patients worldwide. We provide the first documentation of four different tick-borne zoonotic pathogens in an established population of blacklegged ticks, Ixodes scapularis, located in eastern Canada. Using real-time and nested PCR we detected 4 pathogens in …

Objective: Analyze the differences in the detection results of Alzheimer’s Disease (AD) serum biomarkers and the expression of APOE and SLCO1B1 genotypes, then construct an AD diagnostic model integrating serum biomarkers with APOE and SLCO1B1 genotypes to enhance the sensitivity and specificity of AD screening. Meth…

This study investigates hydrogen generation from the reaction of aluminum and water using aluminum hydroxide synthesized under different conditions as a catalyst. The catalysts were prepared using sodium aluminate, aluminum nitrate, aluminum chloride, graphite-assisted precipitation, and re-precipitation from inactive …

In order to maintain the outer diameter without increasing the number of stages of the fan at a given outer diameter and rotational speed of the axial fan, the theoretical analysis and CFD analysis of the fan with conical hub are carried out. Theoretical analysis confirmed that the fan of this configuration can increas…