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Background: Liver Cirrhosis (LC) is associated with significant bone metabolic disorders and an increased risk of fractures. While the problem is recognized, data on vitamin D metabolism and bone remodeling in patients with non-alcoholic and non-viral LC remain limited.Aim: To conduct a comprehensive assessment of vita…

We report on highly sensitive label free optical biosensing of proteins based on nematic liquid crystals. The principles of biosensing are related to the change in the liquid crystal alignment induced by biomolecules adsorbed on the cell inner surface, which can be easily detected with a polarizing optical microscope. …

Background: Wearable technology and multidimensional data analysis present significant opportunities for the continuous, real-time monitoring of cognitive overload, potentially identifying early warning signals before performance degrades. However, key challenges exist, including ensuring data security, sensor accuracy…

Presented are the results of the analysis of the published data on the interaction of Polycyclic Aromatic Hydrocarbons (PAHs), known carcinogenic compounds, and their toxic metabolites, with human transporters. The results of the study show that¸ the compounds interact with human transporters as substrates (with 44% o…

Natural polymers are derived from agriculture, forestry and marine products or isolated from their wastes. The use of biopolymers, as opposed to synthetic polymers, offers significant advantages by reducing environmental impact and minimizing potential health risks. This study focuses on three polysaccharides (Cellulos…

Nanosilver (AgNPs) is widely used in various manufacturing sectors, including agriculture, food processing, and medicine. Many consumer products used in everyday life release silver either as ions or nanoparticles. Without proper regulation, consumption of Ag-containing materials will lead to significant risks for ecos…

The purpose of this study was to identify clinical, academic and research skills gained through a Doctorate in Clinical Laboratory Sciences (DCLS) degree program that enhanced graduates’ effectiveness as educators. A sequential explanatory mixed methods study was conducted using a survey and follow-up zoom interviews…

Background: Fathers’ mental health is increasingly recognised as an essential component of child development and family well-being. However, in low- and middle-income countries like Ghana, research on paternal psychological health and its influence on parenting remains limited.Aim: To examine the relationship between…

Emerging evidence from both human and animal studies indicates that circadian rhythm disruption during critical developmental periods can have profound long-term consequences for cardiovascular health. This review synthesizes current knowledge on the impact of maternal circadian disturbance during pregnancy on cardiac …

The escalating burden of chronic Non-Communicable Diseases (NCDs)-including Cardiovascular Disease (CVD), Type 2 Diabetes Mellitus (T2DM), obesity, hypertension, and cancer-highlights the failure of symptom-based medicine to address root causes. Lifestyle medicine now stands as a transformative alternative, with two pr…

The ketogenic (keto) diet, characterized by high fat, moderate protein, and minimal carbohydrate intake, has surged in popularity due to its perceived efficacy in rapid weight loss. Nevertheless, accumulating evidence highlights significant health risks, particularly exacerbating cardiovascular morbidity in patients wi…

The physiological activity of stomach and esophagus is often impaired by the onset of various diseases such as Gastroesophageal Reflux Disease (GERD), esophagitis, hiatal hernia, tertiary esophageal waves, Barrett’s esophagus, achalasia, gastritis, peptic ulcers, esophageal and gastric cancer.These pathologies presen…

This review provides an in-depth examination of the tumor microenvironment, macrophages, and PD-1 checkpoint inhibitors. It delves into the fundamental aspects of the tumor microenvironment and macrophages, discussing the evolution of key concepts, the involvement of macrophages in tumor progression, and their interact…

Background: Bone and brain metastasis are common in the NSCLC, and tumor environment has played a vital role in the metastasis, endothelial cells are a key component of the tumor microenvironment and its role in the development need to be investigated.Methods: We collected three scRNA‑Seq datasets: GSE254379, GSE1319…

This paper proposes a set of non-parametric statistical functions designed to analyse non-linear systems within the context of refined educational management. Recognizing the limitations of traditional parametric methods—particularly their reliance on stringent distributional assumptions this research develops a comp…