Arteriosclerosis Obliteran (ASO) is a local manifestation of systemic arteriosclerosis in the lower extremity arteries. ASO is a chronic progressive disease caused by arteriosclerosis, such as intimal thickening, lumen stenosis or occlusion of the blood supply arteries of the lower limbs, insufficient blood supply of the diseased limbs, and clinical manifestations such as intermittent claudication, decreased skin temperature, pain, and even ulceration or necrosis of the lower limbs. Its pathogenesis is complex, the treatment is difficult and has gradually attracted extensive attention in clinic. In recent years, more and more studies have shown that hyperhomocysteinemia is an independent risk factor of atherosclerosis, but there is no clinical report on hyperhomocysteinemia and ASO. Therefore, this paper reviews the correlation between hyperhomocysteinemia and ASO, in order to provide theoretical basis and support for the follow-up study of ASO.