We showed different cases and operative treatment of traumatic fractures of humeral shaft including operative treatment by means of external fixation, intramedullary fixation with long humeral nailing, intramedullary fixation with Rush nail and plate osteosynthesis. The indications were chosen according to fracture anatomy and biology but foremost by specific socioeconomic comorbidities and aspects of the patient itself. Bone healing status, postoperative local status, neurocirculatory status, postoperative physical therapy course and overall functional results of injured limb and patient satisfaction.