Sale, located along the Atlantic Ocean, is the third-largest city in Morocco. The Bouregreg river separates Sale from Rabat (Morocco’s capital city). This City is characterized by a high demographic density. Their main air pollution sources are traffic, ocean, potteries, fishing, domestic heating, and artisanal activities. Ambient PM2.5 particles were collected in an urban area of Sale City (Morocco) from July 2018 to July 2019. The sampling was carried out using a Dichotomous sampler and the Total X-Ray Fluorescence technique (TXRF) was used to evaluate the elemental composition of the collected filters. In this paper, chemical characterization, and source apportionment of PM2.5 were investigated. The results showed that the PM2.5 mass concentrations vary, during the sampling period, from 3.08 µg/m3 to 49.48 µg/m3 with an average of 17.30 µg/m3. The highest values were observed in winter while the lowest in summer. The influence of atmospheric transport scenarios on the levels of PM was carried out using air mass back-trajectories, using the HYSPLIT™ model. This study allowed identifying four main clusters arriving at our receptor site in Sale City: Iberian Coast (24%), Near Atlantic Ocean (33%), Local (28%), and Oceanic (15%). For seasonal variations of metal concentrations, K, Ca, V, Mn, Fe, Ni, Cu, Zn, As, Sr, Ba, and Pb exhibited their highest concentrations during winter while Ti and Cr, their highest concentrations were observed during Autumn. The Enrichment Factor (EF) analysis showed that Ti, Sr, Mn, K, Ca, and Ba are mainly originated from airborne dust with EF < 10, V, Cu, Cr have both natural and anthropogenic sources with 10 < EF < 100, while Ni, Zn, and Pb were mainly from anthropogenic source with EF > 100. Five factors were selected in Positive Matrix Factorization (PMF) model’s analysis: crustal contribution, road dust, brake wear, heavy oil combustion, and exhaust vehicle emissions. Their contributions to PM2.5 were 5%, 53.6%, 20.1%, 14.3% and 7%, respectively. Road dust and vehicle exhaust sources showed the highest contribution in winter; while soil dust, brake wear, and oil combustion sources contributed the most in summer. The present study could be considered as the first source apportionment study on PM2.5 fractions carried out in Sale City, Morocco.