Genetics & Stem Cell Research
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Recent Articles
22 articles
Open Access
Research Article 18 Oct 2025
HIF-1α Promotes Osteogenic-Angiogenic Coupling Response of BMSCs Cell Sheets
Background: There is a critical need for management of vascularization in bone tissue engineering. The purpose of this study was to use Hypoxia-Inducible Factor-1α (HIF-1α) transduced Bone Marrow Mesenchymal Stem Cells…
332 Views 75 Downloads
Open Access
Original Article 28 May 2025
Differential Proteomic Profile in the Amniotic Fluid of Pregnancies with Trisomy 21
Background: The precise analytical-clinical characterization of pregnancies carrying the most frequent aneuploidies has now been surpassed by the technical capacity to obtain their proteomic profile. Amniotic fluid conta…
538 Views 87 Downloads
Open Access
Review Article 20 Jan 2025
Cell-Free Therapy Based on Adipose Stem Cell-Derived Exosomes to Inhibit Scar Formation Proactively: Mechanisms and Clinical Targeting Applications
This review provides an in-depth analysis of the potential benefits of cell-free therapy based on adipose-derived exosomes (ADSC-Exos) in inhibiting scar formation. The review highlights the advantages of using ADSC-Exos…
533 Views 151 Downloads
Open Access
Mini Review 31 Aug 2024
Epigenetic Changes in Middle Eastern Women Due to Environmental Exposures: A Mini-Review
256 Views 89 Downloads
Open Access
Case Series 02 Jul 2024
Utilizing Fetal MRI and Prenatal Medical Exome Sequencing for Prenatal Diagnosis of Kinked Brainstem: A Case Series
Objective: Utilizing fetal MRI and prenatal Medical Exome Sequencing (pMES) for prenatal diagnosis in fetuses exhibiting a kinked or 'z-shaped' brainstem.Methods: A retrospective analysis was conducted on cases of brains…
419 Views 56 Downloads
Open Access
Research Article 26 Apr 2024
The Role of the RPD3 Complex of Saccharomyces cerevisiae Yeast in the Activation of UV-Induced Expression of RNR Complex Genes
Reparative chromatin assembly is an important step in maintaining the stability of the genome. Proper chromatin assembly is provided by histone chaperones. Violation of the function of these proteins can lead to the deve…
963 Views 82 Downloads 2 Citations
Open Access
Research Article 29 Mar 2024
The Effects of Vernalization and Photoperiod Genes Composition on Heading Date in Wheat
The vernalization characteristics of wheat are mainly controlled by vernalization and photoperiod genes, which determine the winter-spring habit and heading-flowering of wheat, and affect its environmental adaptability. …
2,696 Views 108 Downloads
Open Access
Mini Review 21 Oct 2023
Decoding Microbial Networks: An Insight into 16S rRNA and Whole Genome Sequencing Approaches in Metagenomic Studies
The exploration of microbial communities is pivotal in understanding environmental, human, and animal ecosystem dynamics. Advances in high-throughput sequencing technologies have significantly enriched our insights into …
2,568 Views 100 Downloads 5 Citations
Open Access
Review Article 30 Sep 2023
The Art of Nanoimmunobiotechnomedicine in Stem Cells and Gene Editing
This comprehensive review provides an exploration of Nanoimmunobiotechnomedicine (NIBTM) within the arenas of stem cells and gene editing. Encompassing the interdisciplinary amalgamation of nanotechnology, immunology, bi…
5,796 Views 104 Downloads 1 Citation
Open Access
Original Article 10 Aug 2023
Unveiling the Role of MX1 and MX2 Gene Expression in Early Pregnancy of Kari Ewes: Insights into INF-tau Signaling and Potential as a Predictive Biomarker for Pregnancy Detection in Domestic Ruminants
Myxovirus resistance (MX) genes are relevant to a family of interferon (IFN)-stimulated genes. In domestic ruminants such as ewes and cattle, the MX genes have two isoforms called the Myxovirus Resistance 1 (MX1) gene an…
1,304 Views 97 Downloads 1 Citation
Open Access
Commentary 30 Mar 2023
Kanemi Yusho and Transgenerational Epigenetic Inheritance
“Kanemi Yusho†was caused by the contamination of heated Polychlororinated Bisphenyls (PCBs) for deodorization in the manufacturing process of rice bran oil at the Kanemi Warehouse Co. Ltd., (Kokura-ward, Kitakyushu,…
1,858 Views 86 Downloads
Open Access
Original Article 20 Jan 2023
Improvement of Bacterial Transformation Efficiency Using Biopolymers as Plasmid Complements
The process of bacterial transformation results from the introduction of specific genetic material into bacteria cells and subsequent gene expression. This technology has significant applications in gene cloning technolo…
2,595 Views 93 Downloads
Open Access
Review Article 09 Aug 2022
Mechanisms of PD-L1 Regulation in Tumor Immune Ecosystem
PD-1 (Programmed Death Receptor-1) is a cell membrane protein found on Cytotoxic T cells (CTLs) surface. An abundantly expressed type I transmembrane protein in healthy tissues, Programmed Death-Ligand 1 (PD-L1), has a m…
1,660 Views 75 Downloads
Open Access
Review Article 30 Apr 2022
Extra Chromosomal Circular DNA: Recent Advances in Research
Extrachromosomal circular DNA (eccDNA) is a circular DNA molecule outside of eukaryotic staining, in which DNA forms in the genome or exogenous DNA in the cell. eccDNA is a special class of genetic material that can carr…
3,086 Views 86 Downloads 1 Citation
Open Access
Case Report 26 Apr 2022
Myeloid Sarcoma of the Paranasal Sinus as Solo Manifestation of Acute Myeloid Leukaemia
Myeloid Sarcoma (MS) is an extramedullary manifestation of Acute Myeloid Leukemia (AML) but it can be the only manifestation of the disease [1,2]. The disease can involve any body site usually as isolated lesion and invo…
2,102 Views 82 Downloads
Open Access
Review Article 20 Nov 2021
Emerging Therapeutic Role of CDK Inhibitors in Targeting Cancer Stem Cells
Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of a normal stem cell thus contributing towards aggressiveness of cancer by playing crucial role in tumor recurrence and metastasis capabili…
1,883 Views 68 Downloads 2 Citations
Open Access
Review Article 20 Oct 2021
A Brief Review of Ideal Bio-Indicators, Bio-Markers and Determinants of Endemic of Fluoride and Fluorosis
Fluorosis in man and animals is the resultant of chronic exposure of Fluoride (F) for prolonged period through F contaminated drinking water and foods and industrial F pollution. However, fluoridated water and industrial…
1,262 Views 80 Downloads 7 Citations
Open Access
Research Article 27 Jul 2021
Research Progress in the Repair of Peripheral Nerve Injury with Adipose-Derived Stem Cell Exosomes
The repair of peripheral nerve injury has always been a difficult clinical problem. Although a variety of treatment methods are available in clinical practice, their efficacy is limited. In recent years, the components c…
13 Views 122 Downloads
Open Access
Research Article 24 Mar 2021
Cord Blood Haematological Parameters Reference Range Difference in Urban and Rural Population of West Bengal as Compared to Global Scenario
Background: Human umbilical cord blood is often discarded as a biomedical waste. We aimed to standardise a local cord blood reference range for the West Bengal population. The cord blood haematological values differ depe…
1,652 Views 76 Downloads 1 Citation
Open Access
Research Article 06 Mar 2021
Beta-Chitosane as a Treatment for Ulcerative Colitis: Therapeutic Effectiveness and Possible Mechanisms of Action
Purpose: Colitis is a widespread inflammatory bowel disease with heterogeneous etiology (genetic and immunological). It is treated with drugs such as steroidal and non-steroidal anti-inflammatory that, in the long term, …
2,019 Views 239 Downloads
Open Access
Review Article 12 Nov 2020
Sex and Age Differences in Telomere Length and Susceptibility to COVID-19
Background: Telomeres are the ends of a chromosome and play a fundamental role as vanguards contra the chromosomal decay. Due to the inability of DNA polymerase to replicate chromosomal ends, a reduction in telomeres len…
10,407 Views 459 Downloads 6 Citations
Open Access
Original Article 07 Aug 2020
Effects of Root Bioaccumulation of Arsenic and Mercury on the Expression of the Nramp2b Gene in Prosopis Alba (Griseb)
Finding of vegetal species suitable for ecologic restoration in arid climates is a primary goal of most of the governmental and private companies for fighting against the desertification and the recovery of contaminated …
3,474 Views 712 Downloads