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Kikuchi-Fujimoto Disease is a rare, benign, self-limiting cause of lymphadenopathy, typically characterized by fever and tender cervical lymph nodes, affecting mostly young women. Clinicians should consider Kikuchi disease in the differential diagnosis of causes of lymphadenopathy to avoid misdiagnosis as lymphoma, systemic lupus erythematosus, tuberculosis or infectious mononucleosis, thereby preventing unnecessary aggressive treatments.