Cecilia Paolini is a Professor in the Department of Neuroscience, Imaging and Clinical Sciences, at the University “G. d’Annunzio” of Chieti-Pescara (Italy), where she has been a faculty member since 2008. After her Bachelor of Sciences degree she went to Pennsylvania PA (USA), at UPenn School of Medicine as Visiting Researcher, where she started her career in muscle structure that continued with the PhD program and the postdoctoral fellowship. Following her return to Italy, she became faculty member and since then, her research interests lie in the area of muscle physiopathology. The main focus of her research is to study structures involved in excitation-contraction (EC) coupling in skeletal muscle fibers using a combination of light, confocal and electron microscopy. She has characterized the phenotype of mice lacking calsequestrin type-1 (CASQ1), the main Ca2+ buffer of the sarcoplasmic reticulum (SR) and a major player in EC coupling, involving also studies on progressive myopathies in different mouse models. She has collaborated actively with other researchers all over the world, as expert of morphological aspects in skeletal muscle. Over the years, she received fundings from the Ministry of Health and from the Ministry of Education, University and Research in Italy.