Background: The joint interest of clinicians and the laboratory test industry during the recent pandemic of the Coronavirus Disease 2019 (COVID-19) resulted in an explosion of accessible assays for COVID-19 serological testing.

Content: The need of properly evaluated laboratory tests is more apparent today than ever before. Clinical application of the assay, analytical specifications, and performance convenience are the key criteria that must be followed while selecting an analytical method. An analytical evaluation is always performed before deciding to apply a procedure in the laboratory routine practice.

Summary: Only after the evaluation, data collection, and analysis of the results in accordance with the established eligibility criteria can be concluded that the new assay is suitable for laboratory use.