COVID-19 and the new variant are a classic example of viral and environmental toxicology link. Observing literature related spread velocity and diffusion of this respiratory virus it is clear the role played by air pollution. The high rate of this environmental pollutant produced a worsening factors that increased mortality rate also.

Two major effect was observed: a proinflammatory effect on the lungs of patient due by the air pollutants like NO2, Particulate matter and many other typical substantie.

A chronic exposition to this toxic produce an inflammatory status as seen in other respiratory classic disease as ASTMA, BCPO and other. Another great contribute is played by the role of CARRIER that PM produces: This particulate matter carry on respiratory tract bioaeresols with viral particle (it seem in a level not able to produce a clinical infection) but also other dangerous substantie like BENZO -A-PYRENE.

This substantie contribute IL proinflamatory effect and also are able to provide a MUTANT AGENT environment involved also in VARIANT production. (See literature reported).

Many world zone with air pollution was involved in first wave of COVID-19 like Wu-Han but also in north Italy and also involved in VARIANT explosion (MANAUS and other). So we can consider this pathology not only an infectious disease but also an environmental toxicological problem.

Climate change, humidity level, air pollution, UV irradiation, PM, high industrialized regions and other environmental factor are involved in this pathology.
Now are produced vaccines but the emerging of the new variant can be a real problem. But what it is relevant is to recognize also in international world organization that air pollution play a non-secondary role.