Introduction: Online learning is a virtual learning system that integrates internet connection with teaching and learning process. This system has become a solution for the continuity of teaching and learning process in Nepal during Covid-19 pandemic. Thus the main objective of this study was to assess the perception of nursing students towards online classes during Covid-19 pandemic.

Methods: A cross-sectional study was carried out among 133 nursing students studying at Gandaki Medical College of Nepal. Data were collected through online survey using a semi-structured questionnaire from 15 to 21, September, 2020 and were analyzed using Statistical Package for Social Science (SPSS) version 16 employing descriptive and inferential statistical method.

Results: The result showed that mobile was the most commonly (51.9%) used gadget for attending online class. One third of the students (35.3%) had no access to static internet and 4.5% of them did not have internet at their home. Majority of the students (91.7%) felt that online classes should be continued during this pandemic. Nearly two third of the respondents (63.2%) were satisfied from the online classes. Overall, 54.1% had negative perception towards online classes. There is statistically significant association of perception with residence (p = 0.033), type of nursing programme (p = 0.027), family income (p = 0.022), education level of father (p = 0.029) and mother (p = 0.004).

Conclusion: Online learning method is a solution taken by higher education in Nepal during the Covid-19 outbreak. Based on the survey result, almost half of the respondents had negative perception towards online learning. However, majority felt that online classes should be continued during this pandemic. Therefore, it is recommended to foster face to face interaction between students and teachers and to promote learning environment at home for online learning.