We here report on a case of a 46-year-old male under evaluation for persistent long-term (for more than 20 years) Hypertriglyceridemia (HTG) submitted to us for a genomic study based in an exome analysis of a mixed dyslipidemia, with Hypercholesterolemia (HC) and HTG (in multiple serum determinations, in recent years on Abbott Alinity Chemistry Analyzers), with unequal response to treatment (with statins for HC, and fibrates for HTG), with a progressive decrease in cholesterol values (now at almost optimal values of LDL cholesterol, around 125 mg/dL) while with no effect on TGs measurements (commonly around 600 mg/dL).