Epilepsy is a rigorous transmission of electrical impulses across neurons of the brain and reported more prevalent in lower-income countries. A systematic literature review has been performed to implicate the impact of environmental variables on the occurrence of epilepsy using the following keywords: Epilepsy or environmental risk factors or seizures. More than 500 genes have been reported to involve in epilepsy potentially. Moreover, family history with neurological disorders, sleep apnea, depression, alcohol, stress, diet, gestational period of mother, and social involvement are among the risk factors which can reliably predict onset and severity of the disease. Hence, minimizing these factors along with recommended therapies, counseling, and awareness could be a miracle in the life of epileptic patients and can improve societies.