Various aspects of human life are organized in Muslim community, including health problems. Islam highly upholds the health in which many people are deceived from such health. One of the efforts that can be done to maintain the health given by god is to implement clean and healthy living behavior in families, schools and others. This research was conducted at Mosque of Antang, Makassar. This research was conducted using Cross Sectional design. The sample used as many as 40 respondents; data analysis used is univariate and bivariate with chi-square test. The results of statistical tests of hand washing orders and defecation obtained a value of p value of 0.000, and smoking prohibition obtained a value of p value of 0.001, the test results showed that there is a relationship between hand washing orders, defecation and smoking prohibition with clean and healthy living behavior, because the calculated value of P < α = 0.05. Based on the research, it can be concluded that clean and healthy living behavior of applied mosque antang is in the good category. Where they are washing their hands, make latrines and without smoking because of the encouragement of faith in their hearts, fear and obedience to the command of god and the magnitude of their love for the messenger. Therefore, it is expected through this research that the People of Indonesia to further increase faith and following to god and love and practice of the Messenger of God in daily life.