A 45-year-old male patient with the nature of sedentary lifestyle, diagnosed with obesity (BMI-33.2 kg/m2) since 2013, was visited for Integrated Yoga and Naturopathy Management (IYNM) for the weight reduction in our hospital on November 2019. He had mild pain over the both knees with sleeping disturbances. We advised him a tailor made individualized protocol for the weight management for the period of 6 months. The results showed reduction in weight (107.9kg to 90.6kg), Body Mass Index (BMI) (33.2kg/m2 to 29.32kg/m2), total cholesterol (209mg% to 185mg%), triglycerides (172mg% to 113mg%), Low Density Lipoprotein (LDL) (102mg% to 94mg%), and High Density Lipoprotein (HDL) (44mg% to 48mg%). His knee pain minimized on discharge as observed on a Visual Analog Scale (7 to 3 points). He had an improved feeling of wellness and overall functional health. This case report suggests that lifestyle change in the form of IYNM is useful in the management of Obesity.