In fusion reactors, radioactivity can be controlled by effective material selection. Material selection is always important for efficient conversion of radioactivity to electrical energy.The selection of structural materials provides more efficient use of these structural materials with the results obtained from nuclear reactions. Low activation materials not only high in structural material performance and longer life, but also minimize related problems. Iron is an important element in fusion reactor technologies and astrophysical applications. For this reason, we obtained the theoretical cross-section values of the 54Fe(α, n)57Ni reaction in the range of 5-15 MeV (Mega electron volt) in this study. TALYS 1.8 (nuclear model code system) and NON-SMOKER (computer code) were used for theoretical calculations. Astrophysical S-factor values describing reactions at low energies were also calculated. In addition, reaction rate values were calculated with TALYS 1.8 and compared with EXFOR (experimental nuclear reaction data).